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Dersom du har brukt sterke smertestillende i mer enn fireplace uker, bør dosen trappes ned i samråd med legen. Dette kan være aktuelt når medisinen ikke gir ønsket effekt eller dersom du får plagsomme bivirkninger. Du må også ha forsøkt minst tre forebyggende legemidler mot migrene. Behandlingen med disse må ha vært uten tilstrekkelig e